Products in Development
We’re researching and developing a number of drugs that target various cellular processes hypothesized to be relevant to dog aging.
LOY-001
LOY-001 specifically targets a cellular mechanism that is hypothesized to cause large and giant breed dogs to age faster and have shorter lifespans than their small-breed companions.
Pilot studies have shown that LOY-001 safely and efficaciously modulates the target biomarker.
We expect LOY-001 will enter clinical trials in 2023.
Proof-of-Concept Complete
Laboratory Pilot Studies Underway
Pivotal Field Study Not Started
Not Yet FDA Approved
LOY-001 Potential Outcomes
More, Healthier Years of Life
On average, small breed dogs like Chihuahuas can live up to 2X longer than giant breeds. LOY-001 is targeting one of the biological mechanisms thought to cause this lifespan disparity.
The drug is thought to work in part by slowing the rate of aging, therefore extending the number of healthy years the dog lives.
Metabolic Fitness
A healthy metabolism is fundamental to fueling a healthy body. Just like humans, dog’s metabolic fitness declines with age. You may notice that older dogs tend to get chubbier, tire faster, and sleep more. A core measure of metabolic fitness is glucose (sugar) metabolism. Early studies of LOY-001 have shown improvements in glucose metabolism and insulin levels.
Preventative Medicine
LOY-001 is hypothesized to work best as a preventative treatment.
In clinical studies LOY-001 will be given to generally healthy dogs to assess whether they stay healthier, longer.
LOY-002
This candidate is targeting a mechanism that, in mice and humans, has shown notable improvement in cognitive function and all-cause mortality.
Laboratory and field pilot studies are currently underway. We expect to enter clinical trials in 2022.
Proof-of-Concept Complete
Laboratory Pilot Studies Underway
Pivotal Field Study Not Started
Not Yet FDA Approved
LOY-002 Potential Outcomes
For Older Dogs of Any Size
While LOY-001 is primarily designed for preventative use in young, large-breed dogs, LOY-002/3/4 are in development for use as an acute treatment after symptoms of cognitive and physical aging have onset.
This product is in development for dogs of all sizes.
Canine Chronic Kidney Disease
Your dog’s kidneys are responsible for filtering out toxins and waste from their blood. Aging can cause the kidneys to function less well, damaging your dog’s health. There is currently no cure for Chronic Kidney Disease, and the disease is terminal.
Dog Cognition
As your dog ages, you may notice that she is sleeping poorly, disoriented and anxious, or house-soiling. This is due to what is colloquially known as "Doggy Dementia". Just like humans, many dogs experience reduced brain function as they get older.
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