Giving our best friends more time
Wally
Tibetan Mastiff
Odin
Whoodle
We’re developing drugs intended to help dogs live longer, healthier lives.
By targeting the underlying causes of canine aging, we hope to prevent and delay the onset of many age-related diseases.
Discover our products Loyal is a clinical-stage veterinary medicine company.
Our work is backed by decades of research on the biology of aging. Our team of experts in dog health and longevity is dedicated to helping your dog live longer by expanding upon this research and developing better ways to quantify the aging process in dogs.
About us 
Wally
Tibetan Mastiff
Join the Loyal list
Sign up today for the latest news on product availability and enrolling your dog in our studies. You’ll also learn about dog aging and wellness from our team of veterinary experts.
Gambit
Lancashire Heeler
Join the Loyal team
We believe aging is one of the most impactful problems you can work on. We are building the best environment to tackle ambitious, challenging goals.
Gambit
Lancashire Heeler
In the news
March 10, 2023
This 30 Under 30 Alumna Is One Step Closer To Helping Your Dogs Live Longer
Read article 
February 3, 2023
More time with your pets? SF biotech company trying to create fountain of youth for dogs
Watch 
November 30, 2022
Biotech startup predicts age of dogs in hunt for clues about human aging
Read article 
August 15, 2022
These scientists are working to extend the lifespan of pet dogs – and their owners
Read article 
November 23, 2021
Founder-led biotech is making space for ideas– and diverse leaders– where it didn’t exist before
Read article 
July 6, 2021
Why this San Francisco anti-aging drug startup thinks it’s barking up the right tree
Read article 
May 26, 2021
How Silicon Valley is helping dogs live longer– so humans can live longer too
Read article 
Publications
November, 2022
Assessment and Management of Declining Physical Function in Aging Dogs ->
McKenzie B, Chen FL. Assessment and Management of Declining Physical Function in Aging Dogs. Topics in Companion Animal Medicine. 2022 Nov 13; 51:100732.
February, 2023
Evaluating instruments for assessing healthspan: a multi-center cross-sectional study on health-related quality of life (HRQL) and frailty in the companion dog ->
Chen FL, Ullal TV, Graves JL, Ratcliff ER, Naka A, McKenzie B, Carttar TA, Super KM, Austriaco J, Weber SY, Vaughn J, LaCroix-Fralish ML. Evaluating instruments for assessing healthspan: a multi-center cross-sectional study on health-related quality of life (HRQL) and frailty in the companion dog. GeroScience. 2023 Feb 13.
August, 2022
Extensive Connections of the Canine Olfactory Pathway Revealed by Tractography and Dissection ->
Andrews EF, Pascalau R, Horowitz A, Lawrence GM, Johnson PJ. Extensive Connections of the Canine Olfactory Pathway Revealed by Tractography and Dissection. J Neurosci. 2022 Aug 17;42(33):6392-407.
June, 2022
The phenotype of aging in the dog: how aging impacts the health and well-being of dogs and their caregivers ->
McKenzie BA, Chen FL, LaCroix-Fralish ML. The phenotype of aging in the dog: how aging impacts the health and well-being of dogs and their caregivers. AVMA. 2022 Jun 1;260(9):963-70.
June, 2022
Comparative veterinary geroscience: mechanism of molecular, cellular, and tissue aging in humans, laboratory animal models, and companion dogs and cats ->
McKenzie BA. Comparative veterinary geroscience: mechanism of molecular, cellular, and tissue aging in humans, laboratory animal models, and companion dogs and cats. AJVR. 2022 Jun 1;83(6).
April, 2022
Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience ->
McKenzie BA, Chen FL, Gruen ME, Olby NJ. Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience. Front. Vet. Sci. 2022 April 21;9:853743.
October, 2021
AdRoit is an accurate and robust method to infer complex transcriptome composition ->
Yang T, Alessandri-Haber N, Fury W, Schaner M, Breese R, LaCroix-Fralish ML, et al. AdRoit is an accurate and robust method to infer complex transcriptome composition. Commun Biol. 2021 Oct 22;4(1):1-4.
September, 2021
Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science ->
Chen FL, Zimmermann M, Hekman JP, Lord KA, Logan B, Russenberger J, et al. Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science. Front. Vet. Sci. 2021 Sept 6;8:662429.