Giving our best friends more time

We’re developing drugs intended to help dogs live longer, healthier lives.

By targeting the underlying causes of canine aging, we hope to prevent and delay the onset of many age-related diseases.
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One step closer to bringing LOY-002 to senior dogs of nearly all sizes

We’ve just launched STAY, a major new clinical study for LOY-002, our drug to extend healthy lifespan in senior dogs.
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What the press is saying about our LOY‑001 news for large dogs

Jumbo, miniature american shepherd whispers in human's ear
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Sign up today for the latest news on product availability and enrolling your dog in our studies. You’ll also learn about dog aging and wellness from our team of veterinary experts.

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We believe aging is one of the most impactful problems you can work on. We are building the best environment to tackle ambitious, challenging goals.
Publications
Frontiers
November, 2023
Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs ->
Graves JL, McKenzie BA, Koch Z, Naka A, Spofford N, Morrison J. Body weight, gonadectomy, and other risk factors for diagnosis of osteoarthritis in companion dogs. Front. Vet. Sci. 2023 November 28; 10:1275964.
Topics in Companion Animal Medicine
November, 2022
Assessment and Management of Declining Physical Function in Aging Dogs ->
McKenzie B, Chen FL. Assessment and Management of Declining Physical Function in Aging Dogs. Topics in Companion Animal Medicine. 2022 Nov 13; 51:100732.
GeroScience
February, 2023
Evaluating instruments for assessing healthspan: a multi-center cross-sectional study on health-related quality of life (HRQL) and frailty in the companion dog ->
Chen FL, Ullal TV, Graves JL, Ratcliff ER, Naka A, McKenzie B, Carttar TA, Super KM, Austriaco J, Weber SY, Vaughn J, LaCroix-Fralish ML. Evaluating instruments for assessing healthspan: a multi-center cross-sectional study on health-related quality of life (HRQL) and frailty in the companion dog. GeroScience. 2023 Feb 13.
JNeurosci (The Journal of Neuroscience)
August, 2022
Extensive Connections of the Canine Olfactory Pathway Revealed by Tractography and Dissection ->
Andrews EF, Pascalau R, Horowitz A, Lawrence GM, Johnson PJ. Extensive Connections of the Canine Olfactory Pathway Revealed by Tractography and Dissection. J Neurosci. 2022 Aug 17;42(33):6392-407.
AVMA (American Veterinary Medical Association)
June, 2022
The phenotype of aging in the dog: how aging impacts the health and well-being of dogs and their caregivers ->
McKenzie BA, Chen FL, LaCroix-Fralish ML. The phenotype of aging in the dog: how aging impacts the health and well-being of dogs and their caregivers. AVMA. 2022 Jun 1;260(9):963-70.
AVMA (American Veterinary Medical Association)
June, 2022
Comparative veterinary geroscience: mechanism of molecular, cellular, and tissue aging in humans, laboratory animal models, and companion dogs and cats ->
McKenzie BA. Comparative veterinary geroscience: mechanism of molecular, cellular, and tissue aging in humans, laboratory animal models, and companion dogs and cats. AJVR. 2022 Jun 1;83(6).
Frontiers
April, 2022
Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience ->
McKenzie BA, Chen FL, Gruen ME, Olby NJ. Canine Geriatric Syndrome: A Framework for Advancing Research in Veterinary Geroscience. Front. Vet. Sci. 2022 April 21;9:853743.
Frontiers
September, 2021
Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science ->
Chen FL, Zimmermann M, Hekman JP, Lord KA, Logan B, Russenberger J, et al. Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science. Front. Vet. Sci. 2021 Sept 6;8:662429.